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Original Article

J App Pharm Sci. 2016; 6(3): 101-106


Antidiarrheal property of Napoleona imperialis may be due to Procyanidins and Ellagic acid derivatives

Peter Chibueze Ihekwereme, Earnest Oghenesuvwe Erhirhie, Ikechukwu Sonne Mbagwu, Emmanuel Emeka Ilodigwe, Daniel Lotanna Ajaghaku, Festus Basden Okoye.

Abstract
Context: Diarrhea is a global epidemic. Majority of the populace in developing Countries including Nigeria depend on Napoleona imperialis as a safer, more effective and affordable alternatives for treatment of diarrhea.
Objective: This study evaluated the antidiarrheal potential of ethanol (leaf) extract and fractions of N. imperialis in Swiss albino mice.
Materials and methods: Acute toxicity test was performed to determine safe dose range before in vivo experiments. Castor-oil induced diarrhea and charcoal meal gastrointestinal motility test models were used. Antimicrobial activity on bacteria-implicated diarrhea, and HPLC analysis of the aqueous fraction (AF) were also evaluated.
Results: The result of the acute toxicity tests show that no death occurred at the test doses. Preliminary antimicrobial screening shows that the inhibitory zone diameter (IZD) of the extract has a weak antibacterial activity against sample organisms. The presence of procyanidin, 9-alpha-OH-pinoresinol, isoprunetin and ellagic acid derivatives in the aqueous fraction were highlighted by the HPLC analysis. The AF produced more significant (P

Key words: Napoleona imperialis, anti-diarrheal, antibacterial, gastrointestinal motility, castor oil, charcoal meal.



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