Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Case Report


Prithvi Varghese, Muhammed Jasim Abdul Jalal, Suhail Ahmad, Ziauddin Khan, Molly Johny, Pushpa Mahadevan, Leena Joseph, Rachel Chandy, Susy Paul.

We report a case of cerebral phaeohyphomycosis caused by a dematiaceous fungus, Fonsecaea monophora, in a patient with type 2 diabetes mellitus and decompensated chronic liver disease. CT brain revealed a 2x2cm hypodense cystic lesion in the right lentiform nucleus region with significant perilesional edema. Stereotactic burr hole aspiration of the lesion with biopsy of the abscess wall was done, and the aspirated pus from the lesion showed branched, septate hyphae with light brown pigmentation. The culture of the pus grew a dematiaceous fungus, identified by morphological and molecular studies as Fonsecaea monophora. The isolate was susceptible to voriconazole (MIC, 0.004 µg/ml) but showed reduced susceptibility to amphotericin B (MIC, four µg/ml). The patient’s caregivers were not willing for a decompressive procedure and hence was treated medically with combined Amphotericin B and voriconazole antifungal therapy. Ultimately, the patient expired due to raised intracranial tension and resultant brain-stem dysfunction. It is the first case of cerebral phaeohyphomycosis caused by Fonsecaea monophora reported from India.

Key words: Brain Abscess; Cerebral phaeohyphomycosis; Dematiaceous fungus; Fonsecaea monophora

Similar Articles

Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation.
Chai WN, Wu YF, Wu ZM, Xie YF, Shi QH, Dan W, Zhan Y, Zhong JJ, Tang W, Sun XC, Jiang L
Neural regeneration research. 2022; 17(1): 163-169

Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.
Jiang C, Wang ZN, Kang YC, Chen Y, Lu WX, Ren HJ, Hou BR
Neural regeneration research. 2022; 17(1): 137-143

Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after experimental traumatic brain injury.
Wang R, Yang DX, Liu YL, Ding J, Guo Y, Ding WH, Tian HL, Yuan F
Neural regeneration research. 2022; 17(1): 130-136

Traumatic brain injury induced by exposure to blast overpressure via ear canal.
Ou Y, Clifton BA, Li J, Sandlin D, Li N, Wu L, Zhang C, Chen T, Huang J, Yu Y, Allison J, Fan F, Roman RJ, Shaffery J, Zhou W, Pang Y, Zhu H
Neural regeneration research. 2022; 17(1): 115-121

Hypoxia inducible factor and diffuse white matter injury in the premature brain: perspectives from genetic studies in mice.
Guo F, Zhang S
Neural regeneration research. 2022; 17(1): 105-107

Full-text options

Add your Article(s) to Indexes
• CiteIndex: Articles & Statistics

American Journal of Diagnostic Imaging


Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.