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Original Article

Biomed Res Ther. 2015; 2(10): 374-384


Significance of p53, pRb and Ki-67 markers in Cervical intraepithelial lesion and Malignancy

Kalyani Raju, Shruthi Suresh Punnayanapalya, Narayanaswamy Mariyappa.




Abstract

OBJECTIVE: To study and to derive the significance of expression of p53, pRb and Ki-67 markers in various grades of cervical intraepithelial lesions and malignancy in a tertiary hospital situated in southern part of India which caters the rural and semi-urban population.

METHODS: A total of 120 cervical tissue samples were included. These represented normal, dysplasia and malignancy. Immunohistochemical staining was performed for p53, Ki-67 and pRb in formalin-fixed, paraffin-embedded tissue sections of the uterine cervix using horse-peroxidase method. Descriptive statistical analysis was done; significance was assessed at 5% level of significance. The mean value of the markers was compared between normal and pathological lesions separately using Independent “t” test.

RESULTS: There was significant association of p53 expression between normal cervical epithelium and low grade squamous intraepithelial lesion (LSIL) (p=0.023), squamous cell carcinoma (SCC) (p

Key words: Cervical carcinoma, Low grade squamous intraepithelial lesion, High grade squamous intraepithelial lesion, Squamous cell carcinoma, Adenocarcinoma, p53, Ki-67, pRb






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