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Original Research



Oxidant and antioxidant mechanisms in chronic kidney disease inflammation in CKD

Ahmet Karatas, Ahmet Bayrak, Tulin Bayrak, Ebru Canakci.



Abstract
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Aim: The objective of this study was to evaluate the correlation of inflammation, oxidant and antioxidant biomarkers with the stages of CKD.
It is well known that inflammation has an important role in CKD. While PON-1 and PAF-AH are biomarkers with antioxidant characteristics, MDA is an oxidant biomarker.
Material and Methods: The participants were divided into 3 groups. Control (n=37) group, non-hemodialysis chronic kidney disease (non-HD CKD) group and hemodialysis group (n=40) . One hudred twenty-one participants were included in this cross-sectional and observational study. Serum PON-1, PAF-AH, MDA levels were measured.
Results: There was a significant difference between the groups regarding the median MDRD values (p

Key words: Chronic Kidney Disease; Platelet-Activating Factor-Acetylhydrolase; Paraoxonase-1; Malondialdehyde.

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010203040506070809101112
2025

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