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The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy

Ramon Satya Pradhana, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, Jimmy Eko Budi Hartono.

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Background: Breast cancer is the most common malignancy in women. Chemotherapy is the main modality for treating breast cancer which affect the cognitive function. Chemotherapy increases the levels of cytokines, damage genetic material, or damage the brain’s grey matter causing cognitive deficits and neurotoxicity.
Objective: To determine the incidence of cognitive impairment before the first injection and after the third injection with an interval of 3 weeks in breast cancer patients receiving chemotherapy and hormonal therapy.
Methods: This was an analytical observational study with a prospective cohort design of postoperative breast cancer patients receiving chemotherapy who met the inclusion and exclusion criteria. Cognitive function tests were carried out using the Moca-Ina questionnaire. Data analysis included descriptive statistics, Mann Whitney test, and Spearman's bivariate correlation test. The results were significant if the p value

Key words: Chemotherapy, Cognitive Function Impairment, Neuropathic Pain

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