OBJECTIVE: To determine the frequency of H. pylori in cases of hepatic encephalopathy with
STUDY DESIGN AND PLACE: Cross-sectional study to observe the role of H. pylori in HE patients
of liver cirrhosis, conducted in Department of Medicine with collaboration to Intensive
Care Unit (ICU) from January 2009 to December 2009 at Liaquat University of Hospital Jamshoro/
RESULTS: Out of 66 patients of HE, 44(66.7%) were male and 22(33.3%) were female, between
20 and 80 years of age. Based on Child-Pough’s criteria, severity of hepatic decompensation
Grading was as; in grade 1= 07 (10.6%), in grade 2= 21 (31.8%), in grade 3= 20 (30.3%) and in
grade 4= 18 (27.3%). Based on Child-Pough’s criteria in class A= 01 (1.5%), in class B= 27
(40.9%) and in class C= 38 (57.6%).
Etiological factors for HE were as; HCV antibodies were positive in 32 (48.48%), HBsAg was
positive among 18 (27.27%), HBsAg and HCV antibodies both were positive in 09 (13.64%), Alcoholics
were 07 (10.6%) and Frequency of H. pylori was found in 47 (71.2%).
CONCLUSION: In our study we found that before and after 10 days H. pylori eradication therapy,
there was no significant improvement in HE grade and other parameters.While the finding of
high frequency of H. pylori in HE patients may be either co-incidence or co-relation that needs
further vast studies.
Liver Cirrhosis, Hepatic Encephalopathy, Helicobacter Pylori Antibodies