Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

J Liaquat Uni Med Health Sci. 2012; 11(2): 105-108

Effect of Methanol Extract of Ajwain (Trachyspermum Ammi L) on Blood Coagulation in Rats

Muhammad Ali Rajput, Rafeeq Alam Khan, Nasreen Qazi and Zeeshan Feroz.

OBJECTIVE: To assess the effect of methanol extract of Ajwain on coagulation parameters PT
and aPTT and to determine usefulness.
DESIGN: This comparative study was conducted in the Department of Pharmacology, Faculty of
Pharmacy, University of Karachi, Pakistan.
METHODS: Antithrombotic tests PT and aPTT were conducted after multiple dosing of Ajwain
on rats using standard kits and reagents, which were performed on Humaclot duo Germany.
The data was subjected to analysis by taking mean and standard error to the mean using student
T- test.
RESULTS: The results revealed that Ajwain extract did not show any significant effect on aPTT
whereas increase in PT was highly significant (P < 0.001).
CONCLUSION: The results suggested that the methanol extract of Ajwain prolonged PT, similar
to that of Warfarin suggesting its possible effects on the extrinsic pathway, while aPTT was not
altered suggesting that it may have no effects on the intrinsic pathway.

Key words: Trachyspermum Ammi (L), Warfarin, Prothrombin time, Activated Partial thromboplastin time.

Full-text options

Full-text Article

Share this Article

Readers of this article also read the following articles

Journal of Environmental and Occupational Science


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.