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Original Article

J Liaquat Uni Med Health Sci. 2012; 11(2): 84-89

Tumour Lysis Syndrome in Haematological Malignancies

Fauzia Wasim, Abdul Manan Khaskheli, Aftab Ahmed Siddiqui, OsamaTariq, Moin Ahmed Ansari.


OBJECTIVES: This study was conducted to determine the frequency of tumor lysis syndrome
(TLS) in haematological malignancies.
MATERIALS AND METHODS: This descriptive study was conducted at Liaquat National Postgraduate
Medical Centre from October 2005 to April 2006 over a period of six months. Total 50
patients with diagnosed haematological malignancies were included in the study and data were
collected by non-probability convenient sampling. Patients pretreated for their malignancy were
excluded from the study. Venous samples for serum uric acid, LDH, phosphorus, calcium,
potassium and creatinine were collected on admission, before starting chemotherapy and
then for four days after starting the chemotherapy. All patients received adequate hydration,
allopurinol and induction chemotherapy. Data were analysed by statistical package for
social sciences (SPSS) version16.0.
RESULTS: Out of 50 patients 10 fulfilled the criteria for TLS. Six patients developed laboratory
tumor lysis syndrome (LTLS), whereas 4 developed clinical tumourlysis syndrome.Acute
renal failure was observed in 4 out of 10 patients. Overall 3 patients died because of TLS. Hyperuricaemia
and lactate dehydrogenase above 2000 IU were the most prominent findings in patients
with TLS.
CONCLUSION: It is concluded that 20% of the patients developed TLS (including both laboratory
and clinical TLS and despite all measures of prevention it can occur and result in devastating
clinical effects.

Key words: Tumor lysis syndrome, hyperuricaemia, hyperphosphataemia, hypocalcaemia, acute renal failure.

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