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Original Article

J Liaquat Uni Med Health Sci. 2012; 11(1): 11-14

Role of Topiramate in Improving Quality of Life in Migraine Sufferers versus Gold Standard Propranolol

M. Jamil Laghari, Nasrin Qazi, Shanawaz Jamali, Ghulam Mustafa.


OBJECT: To assess the role of Topiramate in reducing migraine related disability and improvement
in quality of life in migraine sufferers comparing with conventionally used drug propranolol.
BACKGROUND: Epilepsy and migraine have some biological features in common; therefore antiepileptic
drugs are suppose to be effective in migraine prophylaxis beside active treatment, in
reducing migraine headache attacks and therefore can improve sufferersÂ’ quality of life.
METHODS: Seventy diagnosed patients of migraine were enrolled in the study and 64 completed
the whole study period (12 weeks). They were divided in two groups: A (Topiramate) and
B (Propanolol). MIDAS scores were observed at day-0 and day-90 and results were statistically
RESULTS: Group received Topiramate showed better response and overall reduction was
62.51% (P-value

Key words: Migraine, Prophylaxis, Topiramate, Propranolol, MIDAS(Migraine Disability Assessment)

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