Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article

J Liaquat Uni Med Health Sci. 2012; 11(1): 29-33


Prevalence of Hepatocellular Carcinoma in Cirrhotic Patients of Northern Sindh Attending Liver Clinics at Ghulam Mohammad Mahar Medical College Hospitals Sukkur and Khairpur

Javed Ahmed Phulpoto, Iftikhar Ali Shah, Zulfiqar Bhatti.

Abstract
Despite bearing the main burden of Hepatocellular carcinoma, prospective studies from
developing countries particularly Pakistan are lacking. This prospective observational study
was designed to estimate the prevalence of HCC among Northern Sindh patients with hepatic
cirrhosis.
OBJECTIVE: To assess the prevalence of hepatocellular carcinoma in cirrhotic patients of
Northern Sindh attending liver clinics at Ghulam Mohammad Mahar Medical College Hospitals
Sukkur and Khairpur
STUDY DESIGN: Prospective observational study
PLACE & DURATION OF STUDY: Liver clinic Ghulam Mohammad Mahar Medical College Hospitals
Sukkur and Khairpur, between April 2008 and November 2010
METHODOLOGY: Between April 2008 and November 2010, we enrolled 301 patients with liver
cirrhosis. Patients found to be free of hepatocellular carcinoma (HCC) using baseline abdominal
ultrasound, computed tomography (CT) Scan of abdomen in selected cases and serum alphafetoprotein
(AFP) levels. Patients were followed up prospectively for detection of HCC using
ultrasound and AFP every 6 months, liver biopsy and CT scan of abdomen in selected cases
when required.
RESULTS: Among the 194 patients (mean age [SD] 45.1+13.1 years; male: female 6.1:1.0) followed
up, 154 had Child’s A and 40 had Child’s B disease. The causes of cirrhosis were: hepatitis
B in 71 (36.6%), hepatitis C in 54 (27.8%), dual infection with hepatitis B and C in 12 (6.2%)
and others including autoimmune, alcoholic and cryptogenic cirrhosis in 57 (29.4%) cases. During
a cumulative follow up period of 563.4 person-years, 9 cases of HCC were detected, with an
incidence rate of 1.60 per 100 person-years.
CONCLUSION: In our study, the prevalence of HCC among patients with liver cirrhosis was intermediate,
being lower than that in Japan but higher than that reported from Europe.

Key words: Hepatocellular Carcinoma, Cirrhosis, Incidence, Northern Sindh.






Similar Articles

Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Journal Finder
Covid-19 Trends and Statistics
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
ScopeMed.com
Follow ScopeMed on Twitter
Online Journal Management
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.