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Original Article

J Liaquat Uni Med Health Sci. 2013; 12(2): 74-78


Efficacy of Nepafenac 0.1% in Maintaining Mydriasis during Phacoemulsification Surgery

Sajjad Ali Surhio, Muhammad Memon, Rafeen Talpur, Khalid Iqbal Talpur.

Abstract
OBJECTIVE: To determine the efficacy of Nepafenac 0.1% eye drops in maintaining mydriasis
during phacoemulsification cataract surgery.
METHODS: Patients of 40 65 years of age undergoing phacoemulsificaton cataract surgery
were randomly divided into two groups. One group received Nepafenac 0.1% eye drops and the
other group received placebo (Tears Naturale II eye drops).
Pre operatively; all patients received tropicamide 1% eye drops and phenylephrine 2.5% eye
drops. The surgery in all the cases was done by the same ophthalmologist; with intra operative epinephrine in the irrigating solution. The pupil size was measured with caliper at three
steps; immediately before the surgical incision (baseline), at the end of phacoemulsification,
and at the end of surgery.
RESULTS: 60 eyes of 60 patients were included in the study. 30 eyes were in the Nepafenac
0.1% group and another 30 in the placebo group. The mean age of our patients was 54.18 7.49
years. The mean diameter of pupil at end of surgery was 7.65 0.71 mm in Nepafenac group V/s
6.67 0.97 mm in the placebo group (P Value < 0.001).
In the Nepafenac group; the pupil size at the end of surgery decreased by a mean of 0.55 0.51
mm (range 0.00 1.50 mm). Meanwhile; in placebo group the pupil size decreased by a mean of
1.05 0.87 mm (range 0.00 3.5 mm). This difference was statistically significant (P = 0.009).
CONCLUSION: The pre operative use of Nepafenac 0.1% eye drops was effective in maintaining mydriasis during phacoemulsification cataract surgery.

Key words: Cataract, mydriasis, Nepafenac.



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