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Design of aspirin formulation for rapid pain relief

Meenakshi K. Deepa, Shamla Mehaboob, Suni Narayanan, Praveen Menon, Suman P. Mohanan.

Objective: Aspirin has always had excellent pain relief benefits. To reduce the gastric problems in the present study we had made an attempt to make aspirin fast dissolving tablets.
Methods: Aspirin fast dissolving tablets were developed by direct compression method using Indion 254, Indion 214 and croscarmellose as superdisintegrants. Microcrystalline cellulose was used as diluent, and mannitol, as sweetening agent. The tablets were evaluated for weight variation, mechanical strength, in vitro disintegration time, wetting time and drug release characteristics.
Results: Hardness and friability data indicated good mechanical strength of tablets. The results of in vitro disintegration time indicated that formulation FD3 (containing 5 mg Indion 254) as superdisintegrant was found to be suitable tablets as it showed rapid disintegration within 8 to 32 seconds. Dissolution study revealed the release rate of aspirin fast dissolving tablet and these was compared with that of marketed tablet formulation of aspirin.
Conclusion: It was concluded that superdisintegrants addition technique is a useful method for preparing fast dissolving tablets by direct compression method and present study revealed that Indion 254 could produce good superdisintegrating property.

Key words: Aspirin; Indion 254; Superdisintegrants

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Journal of Environmental and Occupational Science


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