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Original Article

J App Pharm Sci. 2016; 6(3): 058-065


Radiomodulatory Role of Psidium guajava Leaf Extracts against X-ray Induced Genotoxicity, Oxidative stress and Apoptosis in albino Wistar Rat Model

Amith Kumar, Reshma Kumarchandra, Rajalakshmi Rai, B. S. Satish Rao.




Abstract

Psidium guajava is a powerful antioxidant in vitro and can well be used as an antioxidant supplement in vivo, to minimize the damaging effects of radiation within living system, particularly by preventing DNA damage and apoptosis. Further studies with the lead molecule in the extract, may provide valuable tools that may aid in ameliorating the harmful effects of radiotherapy on normal tissues, in cancer patients.

Key words: Psidium guajava, Radiation, Oxidative stress, apoptosis, Comet assay






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