Abstract

Scrub typhus is an acute febrile illness caused by Orientia Tsutsugamushi. It usually presents with high fever, lymphadenopathy, rash, organomegaly, and an eschar formation at the site of bite. Doxycycline is the drug of choice usually showing rapid defervescence, but rarely some cases do not respond. Here we present 2 such cases which did not respond to Doxycycline and had atypical presentation. Our first case presented with fever for 15 days and then went into shock and multiorgan dysfunction despite having no fever after admission. Our second case presented in status epilepticus and septic shock. He developed purpura fulminans even after starting treatment. Both the cases did not respond to Doxycycline. Diagnosis was confirmed by Scrub Typhus IgM Antibody positivity. They were successfully treated with second line drugs i.e. Azithromycin and Chloramphenicol.

Key words: Scrub typhus, Doxycycline resistance, Purpura Fulminans, Acute undifferentiated febrile illness.