Abstract

ABSTRACT
Objectives: To study the changing pattern of antimicrobial resistance of Escherichia coli isolates from patients of urinary tract infections over last three years
Materials and Methods: A retrospective , record based study carried out based on the records of Culture sensitivity (C/S)reports of indoor patients, during past three years (2012 - 2014). The type of organisms most common in urine sample was noted and the drugs still effective for the particular organism were noted .
Results: E.coli was the most frequent isolate throughout the three years (67.66% of the total isolates). Analysis of the results year wise indicated that ¬¬¬ the lowest percentage of resistance was manifested against imipenem between 11.86%(2012)to11.36%(2014) .Resistance for nitrofurantoin decreased over the three consective years from 36.1%(2012) to 18.15%(2014). Over the successive years, resistance to ceftriaxone tends to increase from 53.39 %(2012) to 73.33%(2014). E coli showed absolute resistance (100%) to cotrimoxazole and tetracycline . On an average over the three years E.coli showed high amount of resistances to fluoroquinolones (75%) and aminoglycosides(67%) .While Multi drug resistant (MDR) E.coli range between 63%(2012) to 65%(2014) .
Conclusion: The antimicrobial resistance patterns are constantly evolving and vary from region to region it has become a necessity to do a constant antimicrobial sensitivity surveillance. This will help clinicians to provide safe and effective empirical therapies.

Key words: antimicrobial resistance, Escherichia coli ,urinary tract infections