Recently we observed wound healing activity of 50% ethanol extract of Mallotus philippinensis Muell. Arg (MP) fruit hairs extract (MPE). In several intestinal infections, localized inflammation is of common occurrence and hence we evaluated the anti-inflammatory, analgesic and hypnotic activity of MPE in different rat experimental models. Anti-inflammatory activity was evaluated by carrageenan (acute) and turpentine oil induced formalin (subacute) induced paw oedema and while, granuloma pouch (subacute) in rats. Analgesic and hypnotic activity of MPE was undertaken by tail-flick, hot–plate and acetic acid-induced writhing tests while pentobarbitone-induced hypnotic potentiation respectively in rats. MPE at a dose of 200 mg/kg at 3 hr after their administration showed inhibition of formalin-induced paw oedema by 41.60% (P
Key words: Mallotus philippinensis, carrageenan, formalin, granuloma pouch, Eddy's hot plate, Tail-flick method.
|
