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Original Article

J App Pharm Sci. 2016; 6(2): 135-140


Sildenafil reduces ischemia/reperfusion testicular injury after torsion/detorsion in rats

Marwa M. Abdel-Rahman, Ayman M. Mahmoud, Nevien M. Mostafa, Mohamed E. Saleh, Hassan M. Eissa.

Abstract
This study was conducted to investigate the protective effects of sildenafil citrate on testicular injury after testis torsion/detorsion (T/D) in rats. Forty adult male Wistar rats were randomly allocated into four equal groups of ten rats each. Group 1 (Sham-operated); Group 2 (torsion for 2 hours and detorsion for 2 hours); Group 3, (torsion for 2 hours, sildenafil injection and detorsion for 2 hours), and Group 4 (sildenafil injection, torsion for 2 hours and detorsion for 2 hours). The levels of lipid peroxidation (P

Key words: Ischemia-reperfusion, Testicular torsion; Sildenafil citrate; Inhibin B; Oxidative stress.



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