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Original Article

J App Pharm Sci. 2016; 6(2): 135-140


Sildenafil reduces ischemia/reperfusion testicular injury after torsion/detorsion in rats

Marwa M. Abdel-Rahman, Ayman M. Mahmoud, Nevien M. Mostafa, Mohamed E. Saleh, Hassan M. Eissa.



Abstract
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This study was conducted to investigate the protective effects of sildenafil citrate on testicular injury after testis torsion/detorsion (T/D) in rats. Forty adult male Wistar rats were randomly allocated into four equal groups of ten rats each. Group 1 (Sham-operated); Group 2 (torsion for 2 hours and detorsion for 2 hours); Group 3, (torsion for 2 hours, sildenafil injection and detorsion for 2 hours), and Group 4 (sildenafil injection, torsion for 2 hours and detorsion for 2 hours). The levels of lipid peroxidation (P

Key words: Ischemia-reperfusion, Testicular torsion; Sildenafil citrate; Inhibin B; Oxidative stress.

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