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Original Article

A vascularized nerve graft substitute generated in a chamber bioreactor- A preliminary report

Murat Sinan Engin, Yener Demirtas, Tale Neimetzade, Bulent Ayas, Ibrahim Alper Aksakal, Ahmet Karacalar.

Objectives: Treatments of long peripheral nerve defects are limited and a means to construct a vascularized nerve graft substitute has been sought.
Material and Methods: An in vivo chamber bioreactor was designed with the White New Zealand rabbit’s superficial inferior epigastric pedicle (SIEP) and using autologous Schwann cell (ASC) suspension, a tissue volume containing rich vascularization and a dense presence of Schwann cells was constructed. This construct was comparatively tried on 3 cm of a sciatic nerve defect.
Results: A vascularized build with rich blood supply and an abundance of Schwann cells was engineered and utilized for nerve regeneration and transmission, axonal passage being displayed.
Conclusion: According to the literature review, this is the first achievement of engineering a nerve graft substitute containing vascularized Schwann cells. Therefore, it is believed this study has yielded significant preliminary results, providing a basis for future studies.

Key words: Peripheral nerves, tissue engineering, autologous schwann cells, cell culture, vascularized nerve graft

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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
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