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Original Article

J App Pharm Sci. 2015; 5(12): 001-007


Pharmacokinetics interaction of dapoxetine with different doses of green tea extract in male healthy volunteers using midazolam as CYP3A4 enzyme probe

Khaled Sobhy Abdelkawy, Ahmed M Donia, Mahmoud S Abdallah.

Abstract
This study aimed to investigate the pharmacokinetics interaction of dapoxetine with different doses of green tea extract in healthy volunteers using midazolam (CYP3A4 probe).
Method and materials: Twelve healthy males were included in a random three-way crossover study. Each volunteer received dapoxetine 60 mg and midazolam 7.5 mg concurrently after drinking 250 ml of water, 250 ml of fresh extract of 2 gram of green tea or 250 ml of fresh extract of 4 gram of green tea with one week washout period. Plasma samples were analyzed for dapoxetine and midazolam using HPLC.
Results: The coadministration of dapoxetine with 4 gm grean tea extract significantly increased dapoxetine AUC∞ (from 3218.74 μg.hr/L to 4207.65 μg.hr/L, P

Key words: dapoxetine, green tea, midazolam, CYP3A4, pharmacokinetic, interaction, dose dependant



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