Antioxidant and Immunotropic Properties of some Lithium Salts
Evgenii Plotnikov, Olesya Voronova, Wolfgang Linert, Dmitrii Martemianov, Elena Korotkova, Elena Dorozhko, Anna Astashkina, Irina Martemianova, Svetlana Ivanova, Nikolay Bokhan.
Objective: The antioxidant activity and immuno-tropic effects of lithium glutamate, lithium salicylate, lithium benzoate and lithium lactate have been investigated in this work, as a base for new psychotropic medicines.
Methods: The antioxidant properties were studied by the voltammetric method. Phagocytic activity of neutrophilic leucocytes and the reaction of blastic transformation of lymphocytes were used as test for assessments of influence of the lithium compounds on the immune cells of human blood.
Results: It was revealed absence of toxic action on human blood cells for all tested substances. Lithium benzoate showed the most significant stimulating influence on lymphocytes. Glutamate and benzoate lithium expressed scavenging activity vs oxygen radicals. Salicylate and benzoate lithium revealed significant phagocytosis stimulation effects.
Conclusion: Investigated lithium salts expressed antioxidant activity and immunotropic effects, all investigated substance are of interest in medical application for mental diseases and comorbid pathology treatment.
Key words: antioxidant activity; immunotropic effects; voltammetry; phagocytosis; RBTL; mental diseases; lithium glutamate; lithium salicylate; lithium benzoate; lithium lactate.