Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article

J App Pharm Sci. 2016; 6(2): 109-114


A comparative study of the effect of amikacin administered through autoinjector and manual injection on biochemical parameters in rats

Anitha Roy, R. Vijayaraghavan, R. V. Geetha, Anitha Magesh, S. Vishnu Priya, Anusha Ramasamy, U Vidyalakshimi, K RaagaNamrata, S. Krishna Mohan, Madhan Chakkaravarthy.


Abstract

Objective: The objective was to compare the biochemical changes of amikacin by autoinjector delivery and manual injection in rats.

Materials and Methods: Amikacin drug cartridge (500 mg/2 mL) for autoinjectors was diluted to 63 mg/mL and rats were administered 1 mL, i.p. One group was given 3 and a second group 7 injection on consecutive days. 3 and 7 days manual injection of same dose of amikacin (about 500 mg/kg, i.p.) and a control group (saline) were also included (total 5 groups). On day 4 or 8 biochemical parameters were studied.

Results: Significant increase in urea, creatinine and aspartate aminotransferase were observed in 7 day administration in both autoinjector and manual injection groups compared to control group. All other parameters viz., glucose, cholesterol, total triglycerides, bilirubin, uric acid, total protein, albumin, alanine aminotransferase and alkaline phosphatase did not show any significant change. No significant change was observed in 3 day administration groups.

Conclusion: High dose of amikacin for longer duration is known for its nephrotoxicity which is evidenced by the increase in urea and creatinine in both autoinjector and manual injection groups. This study shows that autoinjector device for amikacin which is new can be considered for further research work.

Key words: Nephrotoxicity, creatinine, urea, Amikacin, autoinjector, biochemical parameters






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net







Do you want to use OJS for your journal ?
work with an experienced partner
www.OJSHosting.net

eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.