Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research

Egypt. J. Exp. Biol. (Zoo.). 2015; 11(2): 133-142


NEUROPROTECTIVE EFFECTS OF GINGER AGAINST SERTRALINE AS ANTIDEPRESSANT DRUG-INDUCED LESIONS IN SPINAL CORD OF MICE

Hala G. EL Tantawi, Nouf K. Alaqeel.

Abstract
Sertraline is an antidepressant drug used for treatment of depression. However, there are several side effects occurred during its use in treatment. Ginger is a natural substance which has many biological effective roles such as immunomodulatory, antioxidant, and free radical scavenging and anti-inflammatory agent. The study was designed to clarify the histological, ultrastructural and immunohistochemical alterations in the spinal cord of male albino mice after ingestion of sertraline and to elucidate of the protective role of ginger extract against the side effects of this antidepressant drug. Forty adult male albino Wister mice were divided into four groups ; group 1 ingested distilled water , group 2 ingested 50 mg/l (10%) ginger extract, group 3 ingested sertraline (0.13 mg/kg/BW), group 4 ingested sertraline and then was given ginger extract after 1 hour. All groups were treated for 28 consecutive days. The animals were sacrificed and the cervical region of the spinal cord from each animal was taken and processed for both light and electron microscopic examinations. Histopathological and ultrastructural studies revealed significant alterations in the motor and sensory neurons of the spinal cord after treatment with sertraline. These changes were confirmed by the immunohistochemical expression results. Sections of animals treated with sertraline followed by ginger revealed marked ameliorative effects. It is concluded that ginger has a protective effect by avoiding the side effects of the sertraline.

Key words: Sertraline, ginger, spinal cord, immunohistochemstry, Ultrastructure



Similar Articles

Chinese Herbal Medicine in Treatment of Spinal Cord Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Zheng Y, Qi S, Wu F, Hu J, Zhong R, Hua C, Jiang D, Quan R
The American journal of Chinese medicine. 2020; 48(7): 1593-1616

Alcohol, ginger, and essential oil blend aromatherapy for postoperative nausea.

AORN journal. 2020; 111(5): P22

Ginger extract activates caspase independent paraptosis in cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage.
Nedungadi D, Binoy A, Vinod V, Vanuopadath M, Nair SS, Nair BG, Mishra N
Nutrition and cancer. 2021; 73(1): 147-159

Modulation of Key Physio-Biochemical and Ultrastructural Attributes after Synergistic Application of Zinc and Silicon on Rice under Cadmium Stress.
Mapodzeke JM, Adil MF, Wei D, Joan HI, Ouyang Y, Shamsi IH
Plants (Basel, Switzerland). 2021; 10(1):

Feeding difficulties in children and adolescents with spinal muscular atrophy type 2.
Wadman RI, De Amicis R, Brusa C, Battezzati A, Bertoli S, Davis T, Main M, Manzur A, Mastella C, Munot P, Imbrigiotta N, Schottlaender L, Sarkozy A, Trucco F, Baranello G, Scoto M, Muntoni F
Neuromuscular disorders : NMD. 2021; 31(2): 101-112

Three-dimensional ultrastructure of giant mitochondria in human non-alcoholic fatty liver disease.
Shami GJ, Cheng D, Verhaegh P, Koek G, Wisse E, Braet F
Scientific reports. 2021; 11(1): 3319

Incidence of Acquired Nontraumatic Spinal Cord Injury in Finland: A 4-Year Prospective Multicenter Study.
Niemi-Nikkola V, Koskinen E, Väärälä E, Kauppila AM, Kallinen M, Vainionpää A
Archives of physical medicine and rehabilitation. 2021; 102(1): 44-49

Management, outcomes, and prognostic factors of adult primary spinal cord gliomas.
Haque W, Verma V, Barber S, Tremont IW, Brian Butler E, Teh BS
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2021; 84(): 8-14


Full-text options






Advertisement
American Journal of Diagnostic Imaging

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.