Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Research



Effect of filgrastim (recombinant human granulocyte colony stimulating factor) on spatial memory in aged rats

Hamid Sepehri, Elham Mehrazin.


Abstract

Background: Apart from functioning as a multimodal hematopoietic growth factor, granulocyte colony-stimulating factor (G-CSF) causes intense consequences on the brain. It has been viewed that G-CSF boosts the improvement from the neurologic deficits in rodent models of central nervous system diseases.

Aims and Objective: To evaluate the efficacy of G-CSF as an intervention for improving cognitive deficits commonly associated with aging.

Materials and Methods: In this study, male Wistar rats aged 21 months were treated for 2 weeks with G-CSF intraperitoneally at doses of 10, 50, and 70 mg/kg/day. The learning process was assessed by the reference memory task in the Morris water maze, by comparing the G-CSF–treated group with the control animals. All the rats received Morris water maze training (four trials/day for 5 days) in order to assess the hippocampal-dependent spatial learning and received a 60-s probe trial test of spatial memory retention 24 h after the twentieth trial.

Result: Over 5 days of training, G-CSF (10, 50, and70 mg/kg/day) significantly reduced the latency and path length to finding the escape platform (P < 0.01). In probe trials (without platform), on the last day of training, the G-CSF–treated group spent significantly longer time in the platform quadrant when compared with the control animals (P < 0.01). Among the treated groups, the 50-mg/kg dosage of G-CSF induced the best rehearsals memory.

Conclusion: The findings observed in this study support G-CSF as a promising therapeutic aid for cognitive enhancement in the aging phenomenon.

Key words: Memory; G-CSF; Filgrastim; Morris Water Maze; Aging






Full-text options


Share this Article



Online Article Submission
• ejmanager.com







eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.