Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Regular Article



Mango (Mangifera indica cv. Azucar) antiinflammatory and chemopreventive role during colorectal carcinogenesis

Andrea Corrales, Gabriela Jaramillo, Berardo Rodríguez, Elhadi Yahia, Maria Elena Maldonado.

Abstract
Chemopreventive activities of natural compounds result in the modulation of several pathways and molecular targets. It is common to find effective potential candidates for cancer chemoprevention with anti-inflammatory properties. Mango (Mangifera indica cv. Azúcar) has shown anticarcinogenic effects and it is a source of bioactive compounds. This study evaluated the effects of mango on Aberrant Crypt Foci formation and inflammatory biomarkers after initiation of colon carcinogenesis in AOM-treated mice. Ripped mango pulp (Mangifera indica cv. Azúcar) composition was identified by HPLC. Azoxymethane-treated mice received the fruit (0.3% w/v) for eight weeks and the distal part of colon was collected and stained with methylene blue to look for aberrant crypt foci (ACF); scrapped mucosal cells were processed for prostaglandin E2 detection by ELISA; and blood levels of pro-inflammatory cytokines ( interleukin 1-Beta, tumor necrosis factor-alpha, interleukin 6) were also assessed by ELISA. Student’s t.test was used for the comparisons between mango treated and untreated groups. ACF formation was reduced by 67.5% and prostaglandin E2 levels were also reduced in mice which ingested the fruit. Cytokines levels were unchanged by mango consumption. In the chromatography were identified phenolic acids and Beta-carotene. Mango pulp showed chemopreventive effects through the reduction of ACF formation, by means of blocking hyperproliferation which is correlated with decreasing levels of PGE2.

Key words: Mangiferin indica, colorectal cancer, chemoprevention, prostaglandin E2, cytokines.


Full-text options

Full-text Article


Share this Article


Readers of this article also read the following articles
»D-dimer levels in etiological diagnosis of ischemic stroke and relationship the prognosis
»Comparison of efficacy of Natural honey and Triamcinolone acetonide (0.1%) in the healing of oral ulcers- A clinical study
»A Study of Students’ Learning Styles in a Medical Institution in Pakistan
»Applications of Transgenic Animal Production for Enhancement of Human Welfare- A Critical Review
»Multiple antimicrobial resistance of Escherichia coli and Salmonella species isolated from broilers and local chickens retailed along the roadside in Zaria, Nigeria
»Assessment of Mass Level Public Awareness Campaigns Regarding Dengue among Parents Visiting Tertiary Care Children Hospital Karachi, Pakistan
»A prospective study of conservative management in cases of hemoperitoneum in solid organ injuries at tertiary care hospital in western India.
»Prevalence of cardiovascular risk factors among adults in rural area of Mangalore
»Effect of methanol extracts of three dietary plants growing in Egypt on mice fed with high fat diet
»SAFETY OF LIPOFILLING AS A SECONDARY PROCEDURE IN BREAST RECONSTRUCTION
»Appraisal of Access to Dental Services in South East of Iran Using Five as Model



Advertisement
Journal of Apitherapy

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.