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Original Article

Med Arch. 2015; 69(4): 232-235


Correlation of Inflammation and Lipoprotein (a) with Hypercoagulability in Hemodialysis Patients

Valdete Topçiu-Shufta, Valdete Haxhibeqiri, Luljeta Begolli, Zana Baruti-Gafurri, Shemsi Veseli, Shpend Haxhibeqiri, Ramë Miftari, Leonard Kurti, Driton Avdiu.




Abstract

Background: Inflammatory and procoagulant markers are potential mediators for the cardiovascular risk in hemodialysis patients. Lipoprotein (a) [Lp(a)], is another important risk factor with inflammatory and procoagulant effects. Materials and methods: In 78 hemodialysis patients and 40 controls, C-reactive protein (CRP), Interleukin-6 (IL-6), lipoprotein (a) [Lp (a)], fibrinogen, D-dimer, von Wilebrand factor (vWF) and serum albumin were determined. Results: CRP, IL-6, Lp(a), fibrinogen, D-dimer and vWF, were significantly higher, and serum albumin was significantly lower in patients compared to controls (24.40 mg/L vs. 6.39 mg/L, p

Key words: inflammation, Lp(a), hypercoagulability, chronic hemodialysis.






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