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Original Article

Med Arch. 2015; 69(4): 212-217

In Vitro Evaluation of Achillea Millefolium on the Production and Stimulation of Human Skin Fibroblast Cells (HFS-PI-16)

Zahra Ghobadian, Mohammad Reza Hafezi Ahmadi, Leila Rezazadeh, Ehsan Hosseini, Taleb Kokhazadeh, Samiramis Ghavam.

Cited by (1)

Aim: In the present study, we aimed the effects of the hydroalcoholic extract of Achillea millefolium (HEAML) on human skin fibroblast cells (HSF-PI-16) proliferation, stimulation and growth properties. Methods: Initially, using HSF-PI-16 monolayer culture, we created one line scratch method as an in vitro wound closure and after 3 days monitored via an inverted microscopy. Results: HEAML selectively inhibited proliferation of HSF-PI-16 cells at higher concentration (>20.0 mg/mL), and stimulated at lower concentrations (

Key words: Fibroblasts, Proliferation, Achillea millefolium, Skin, Culture.

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American Journal of Research in Medical Sciences


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