Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

J App Pharm Sci. 2015; 5(Supplement 3): 040-043

Evaluation on the Bacillus subtilis spore in drug delivery

Tu HK Nguyen, Huu N Nguyen.

Bacillus subtilis spores were used to study on drug delivery nowadays. However, evaluation on the cisplatin packaging and releasing ability in spores is still limitation. In this study, we determined Bacillus subtilis spores (2x108) could be packaged to 54,600,000 drug molecules of cisplatin from 8 to 12 hours. Spores were checked by scanning electron microscope and transmission electron microscope, and then drug release was done. Cisplatin started releasing at 0.5 hours at pH 3.4 (23.8%) that was higher than pH 7.2 (0.5%). Cisplatin released irregularly during 24 hours in pH 3.4. In contrast, the cisplatin releasing was slow and steady during 24 hours in pH 7.2. The release ability was only 25% that meant that cisplatin packing spores would be used in prolonged-release finished products. The study was the first report of the cisplatin-packaged spore and release ability of cisplatin out of spore that could be used in pharmaceutical field.

Key words: Cisplatin, Bacillus subtilis spore, drug packaging, drug release, high performance liquid chromatography

Similar Articles

High-frequency spinal cord stimulation produces long-lasting analgesic effects by restoring lysosomal function and autophagic flux in the spinal dorsal horn.
Wang ZB, Liu YD, Wang S, Zhao P
Neural regeneration research. 2022; 17(2): 370-377

Artisan versus Artiflex phakic intraocular lens implantation in the treatment of moderate to high myopia: meta-analysis.
Hou C, Li H, Li J, Li J, Peng H, Wang Q
BMC ophthalmology. 2021; 21(1): 171

A protein-sulfosalicylic acid/boswellic acids @metal-organic framework nanocomposite as anticancer drug delivery system.
Özsoy M, Atiroğlu V, Guney Eskiler G, Atiroğlu A, Deveci Ozkan A, Özacar M
Colloids and surfaces. B, Biointerfaces. 2021; 204(): 111788

Alternative and Improved Stability-Indicating HPLC Method for the Assay of Eprinomectin and Determination of its Related Compounds in Bulk Batches of Eprinomectin Drug Substance.
Padivitage N, Tian J, Rustum A
Journal of AOAC International. 2021; ():

Synthesis and application of stationary phase for DNA-affinity chromatographic analysis of unmodified and antisense oligonucleotide.
Studzińska S, Zawadzka E, Bocian S, Szumski M
Analytical and bioanalytical chemistry. 2021; ():

Full-text options

Add your Article(s) to Indexes
• citeindex.org

Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.