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Dexmedetomidine effect to lung injury in abdominal hypertension

Ozlem Boybeyi& 775;, Ferda Yaman, Mahi Balci, Mustafa Unlu, Ucler Kisa, Mustafa Kemal Aslan.

Abstract
Objective: An experimental study was performed to evaluate the effect of dexmedetomidine on lung injury secondary to experimental intra-abdominal hypertension (IAH).
Methods: Eighteen Wistar-albino rats were included and allocated into 3 groups - the control group (CG, n=6), the sham group (SG, n=6) and the dexmedetomidine group (DG, n=6). No intervention was made in CG. IAH was achieved by insufflating atmospheric air with a percutaneous intraperitoneal needle up to 15 mmHg pressures in SG and DG. At the 60th min of IAH, physiological serum (1.5 ml/100 grams/hr) in SG and dexmedetomidine (1 mcg/kg/hr) in DG were infused for 30 min through the tail vein. At the 90th min, the left inferior lobes of the lung were harvested for biochemical (nitric oxide-NO, malondialdehyde-MDA) and histopathological (alveolar hemorrhage, edema, congestion, leukocyte infiltration) examination.
Results: There was no significant difference between any of the groups with regards to NO and MDA levels (p>0.05). His- topathologically, although alveolar hemorrhage, edema, congestion, leukocyte infiltration were increased in SG compared to CG and DG, the difference was not statistically significant (p>0.05). There was no significant difference between CG and DG with respect to histopathological grading (p>0.05).
Conclusion: IAP of 15 mmHg in rats causes mild injury in lung parenchyma. The administration of DEX in clinical doses does not seem to significantly affect the lungs of rats.

Key words: Intra-abdominal hypertension, lung injury, dexmedetomidine


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