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Comparison of lipid profile and malondialdehyde with severity of blood pressure in pregnancy-induced hypertension

Shikha Saxena, Prem Chandra Srivastava, Ayaz Khurram Mallick, Biswajit Das, Kamandalagondi Vasudevareddy Thimmaraju, Kanchan Dalmia.

Background: Abnormal lipid profile and increased lipid peroxidation have a basic role in pathogenesis of pregnancy-induced hypertension (PIH). The association of dyslipidemia and lipid peroxidation product malondialdehyde (MDA) with severity of PIH has emerged as important diagnostic tool in predicting its progression.

Objective: To establish the correlation of serum lipid profile and lipid peroxidation product MDA with severity of PIH considering systolic and diastolic blood pressure (BP).

Materials and Methods: Study subjects included 70 women with diagnosed PIH and divided into two groups taking cutoff point of systolic BP 160 mm Hg and diastolic BP 110 mm Hg, respectively. Level of lipoproteins and MDA in patients with PIH was compared in both groups of systolic and diastolic BP. Statistical analysis was done by applying independent Studentís t-test, coefficient of correlation r was determined, and p-value

Key words: Pregnancy-induced hypertension, dyslipidemia, malondialdehyde, diastolic blood pressure, systolic blood pressure

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Oxidants and Antioxidants in Medical Science


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