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Original Article

J App Pharm Sci. 2015; 5(Supplement 3): 044-047


Synthesis and screening of new Maleimide derivatives as potential Anti-Tubercular agents

Murali krishna kumar Muthyala, Saroj Kumar Sahoo, kurre Purna Nagasree, Raghuveer varma Pemmadi, Risy Namratha Jamullamudi.

Abstract
In the present investigation a series of new maleimide derivatives were synthesized by reacting different anilines with maleic anhydride in presence of acetic anhydride and sodium acetate. The synthesized compounds were identified by using IR, 1H NMR and mass spectral data analysis. The preliminary in vitro antimicrobial activity was studied against S. aureus, E. coli and A.niger. Further, the synthesized compounds (PA1-PA15) were subjected to in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using MABA method. The compounds PA4 (MIC 6.25 g/ml), PA8 (MIC 3.125 g/ml), PA14 (MIC 3.125 g/ml) showed significant inhibitory activity against M. tuberculosis H37Rv.

Key words: maleimide, antitubercular, 3,4-diarylpyrrole,tuberculosis



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