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RMJ. 2016; 41(3): 300-303

In vitro activity of tetracyclines against multi-drug resistant Acinetobacter baumannii

Afreenish Hassan, Javaid Usman, Fatima Kaleem, Maria Mushtaq Gill, Ali Khalid, Muhammad Iqbal.

Objective: To assess the in vitro sensitivity of multi drug resistant Acinetobacter baumannii (A.baumannii) against four tetracyclines.
Methodology: Routine clinical specimens were received from various wards of a tertiary care hospital from December 2009 to August 2010. A. baumannii was identified by using standard microbiological procedures. Minimum inhibitory concentration (MIC) was performed by using E-strips (AB-Biodisk) of tetracycline, minocycline, doxycyline and tigecycline for each isolate. Results were analyzed by using SPSS version 17.0.
Results: A total of fifty MDR Acinetobacter baumannii were analyzed during the study period. Among the four tetracyclines tested, minocycline was the most effective against MDR A. baumannii. Forty seven (94%) of the isolates were susceptible to minocycline with an MIC90 value 4 ug/mL.
Conclusion: Among tetracyclines, minocycline is an appropriate option against infections caused by MDR A. baumannii. This study will help our clinicians in finding a suitable treatment against such resistant bacteria.

Key words: Acinetobacter baumannii, Minocycline, Minimum inhibitory concentration (MIC)

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