Background/aim: To determine the antihyperglycemic effect of Euphorbia antiquorum L. root.
Materials and methods: The study evaluates the antihyperglycemic effect of E. antiquorum root in Streptozotocin- Nicotinamide induced Type 2 Diabetes mellitus and fructose induced insulin resistance models. Alcohol and aqueous extracts of E. antiquorum root were administered at doses 200 and 400 mg/kg p.o. Serum levels of glucose, total cholesterol, triglycerides, glycosylated hemoglobin (GHb) and hepatic levels of MDA, GSH and glycogen were estimated.
Results: Treatment with the alcohol and aqueous extracts of E. antiquorum roots resulted in significant (P < 0.001) lowering of serum blood glucose and GHb levels in both the models. Flavonoids, phenolic compounds, glycosides were detected in the preliminary phytochemical screening.
Conclusion: Root of E. antiquorum showed promising antihyperglycemic effect which may be due to the presence of important phytochemicals.
Key words: Euphorbia antiquorum, hyperglycemia, insulin resistance, oxidative stress
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