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Inherited stress-induced hypertension associates with altered gene expression of thermosensitive TRP ion channels in hypothalamus

Irina P. Voronova, Anna A. Tuzhikova, Arkadij L. Markel, Tamara V. Kozyreva.

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Objective: The widespread essential hypertension, of which the nature is still unclear, demands a comprehensive study of the differences between normo- and hypertensives. Hypertension may be associated with changes in the central nervous system functioning, at various levels. Our previous data have shown the differences in thermo-responsiveness of normotensive and hypertensive rats. Thermosensitive TRP (transient receptor potential) ion channels which are considered as a molecular basis of the thermosensitivity are essential for thermoregulation. Hypothalamus is the important brain structure for blood pressure and temperature regulation. The aim of present work was to assess the expression of thermosensitive TRP ion channel genes in functionally different parts of hypothalamus in normo- and hypertensive rats.
Methods: Male inherited stress-induced arterial hypertensive (ISIAH) rats and normotensive Wistar Albino Glaxo (WAG) were used. Gene expression was assayed by the quantitative method of reverse transcription-polymerase-chain-reaction (RT-PCR).
Results: Differences between normal and hypertensive rats were found in the expression of transient receptor potential melastatin 8 (Trpm8) and transient receptor potential vanilloid 4 (Trpv4) genes. The level of Trpm8 mRNA in the anterior hypothalamus of hypertensives was more than twice lower than in normotensives. In hypertensives, the level of Trpv4 mRNA in posterior hypothalamus was half time higher than in anterior, and significantly higher than in the normotensives. In normotensives, the Trpv4 gene expression was the same in both parts of hypothalamus. Some differences between anterior and posterior hypothalamus were similar in normo- and hypertensives: the level of Trpm8 mRNA in the anterior hypothalamus was three times higher than in the posterior and the levels of Trpv1 and transient receptor potential ankyrin 1 (Trpa1) mRNA, vice versa.
Conclusion: The obtained data allow to come closer to understand the possible molecular bases of the status of hypertension and elucidate some aspects of the physiological role of the investigated thermosensitive TRP ion channels.

Key words: Gene expression, hypertension, hypothalamus, transient receptor potential channels

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