Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

Expression of p53 and bcl2 in squamous cell carcinoma of head and neck

Kanika Taneja, Sumiti Gupta, Ashok Chauhan, Rajnish Kalra, Aditi Arora, Sohrab Arora, Rajeev Sen.

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth-most common malignancy worldwide. Despite advances in radiotherapy and surgical treatment, survival rates have not changed significantly in the last 40 years. Molecular markers are currently being identified that can determine prognosis preoperatively by routine tumor biopsy, lead- ing to improved management of HNSCC patients.
Aim: The aim of the present study was to demonstrate the expression of p53 and bcl2 proteins in squamous cell carcinoma of head and neck (HNSCC) and to correlate the expression of p53 and bcl2 with clinical staging (AJCC) and WHO histological grading of SCC.
Materials and methods: The study population comprised 50 cases of HNSCC. Tissue sections from these cases were subjected to hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining using p53 and bcl2, and a comparative analysis of the results was performed. Cases of colon carcinoma and benign lymphoid hyperplasia were used as positive controls for p53 and bcl2, respectively.
Results: Positivity for p53 was recorded in 30 cases (30/50), while positivity for bcl2 was recorded in 44 cases (44/50). Positivity for p53+/bcl2+ coexpression was seen in 28 cases (28/50). The frequency of p53 expression was associated with tumor histologic grade (p=0.02), increasing lymph node involvement (p=0.01), and clinical stage (p=0.038). The frequency of bcl2 expression was associated with histological grade (p=0.02) and increasing lymph node involvement (p=0.028), but not with clinical stage (p=0.242). Moreover, the combined p53+/bcl2+ expression was significantly associated with histo- logical grade (p=0.02) and lymph node involvement (p=0.01).
Conclusion: Study of p53 and bcl2 expression may provide clinicians with more exact information in order to evaluate tumor aggressiveness and survival rates.

Key words: Immunohistochemistry, p53, bcl2, head and neck squamous cell carcinoma

Full-text options

Full-text Article

Share this Article

Readers of this article also read the following articles
»Comparison of Manual Therapy Techniques in Adhesive Capsulitis
»Is intensive care unit necessary for geriatric hip fractures?
»A New Example of Unethical Behaviour in the Academic Journal “Medical Archives”
»Prevalence of Bovine Fasciolosis, Amplitude of Liver Condemnation and Its Economic Impact in Municipal Abattoir of Mekelle, Ethiopia
»Therapeutic Effect Of Some Honeybee Products On Alleviating Symptoms Of Osteoarthritis In Male Albino Rats
»Synthesis and in vitro Anti Microbial Evaluation Including Anti-Malarial Activity of Pyrazole Based Novel Cinnoline Derivatives
»The Knowledge of Nurses and Midwives Related to Mentally-Handicapped Children
»Clinical and preclinical professionalism: Perception of undergraduate students
»Surgical and endovascular treatment for mesenteric ischemia
»Hepatozoon species infections in Nigeria

Journal of Molecular Pathophysiology


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.