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Original Article

Med Arch. 2024; 78(2): 88-91

Comparison of UVA vs UVB Photoaging Rat Models in Short-term Exposure

Elly Mayangsari, Arifa Mustika, Nurdiana Nurdiana, Nozlena Abdul Samad.


Background: Prolonged exposure to sunlight is known to induce photoaging of the skin, leading to various skin changes and disorders, such as dryness, wrinkles, irregular pigmentation, and even cancer. Ultraviolet A (UVA) and ultraviolet B (UVB) radiation are particularly responsible for causing photoaging. Objective: This study aims to identify and compare photoaging rat models exposed to UVA and UVB. Methods: This research method compared macroscopic (scoring degree of wrinkling) and microscopic (histology) signs and symptoms on skin samples of rat exposed to UVA and UVB for 4 weeks at a radiation dose of 840mJ/cm2. Results: The results of this study indicated that the degree of wrinkling was highest in rat skin exposed to UVB rays by 51% (p

Key words: Disease, Photoaging model, Short-term exposure, UVA, UVB. Adipocytokines.

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