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The chemopreventive effects of Thysanolaena latifolia against carbon tetrachloride (CCl4)-induced oxidative stress in rats

Charles Gnanaraj, A.T.M. Emdadul Haque, Mohammad Iqbal.

Objective: Present study was undertaken to evaluate the chemopreventive effects of Thysanolaena latifolia against carbon tetrachloride (CCl4)-induced oxidative stress in rats.
Methods: Rats were pre-treated with T.latifolia prior to the administration of CCl4. Hepatic damage and toxicity were evaluated by measuring the levels of serum transaminases, malondialdehyde content, reduced glutathione, antioxidant enzymatic molecules and histopathological changes in rats. Free radical scavenging activity of T.latifolia was evaluated by in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.
Results: Administration of CCl4 to rats (1.2 ml/kg, p.o.) showed a significant elevation of lipid peroxidation and decreased enzymatic and nonenzymatic antioxidants. Consistent with these changes, CCl4 treatment enhances hepatic damage as evidenced by sharp increases in serum transaminases. In addition, the impairment of liver function corresponded with histolopathological changes. Pretreatment of animals with T.latifolia (150 and 300 mg/kg, p.o.) showed significant and dose-dependent protection against CCl4-mediated oxidative liver damage and toxicity in rats. Furthermore, histopathology of T.latifolia treated animals showed tendency toward normalization of cytoarchitecture of liver. T.latifolia was found to possess 20.3 ± 0.72 mg/g total phenolic content expressed as gallic acid equivalent and to scavenge DPPH radical significantly.
Conclusion: It is concluded that T.latifolia possesses significant hepatoprotective effect against oxidative damage mediated by CCl4 in rats, which may be due to its antioxidant and free radical scavenging effects.

Key words: Antioxidant enzymes; Carbon tetrachloride; Liver protection; Oxidative stress; Thysanolaena latifolia

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