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Dynamics of Neutrophil Gelatinase Associated Lipocalin Serum in Malignant Subjects Treated with Chemotherapy

Denny Moniaga, Syakib Bakri, Haerani Rasyid, Tutik Harjiyanti, Hasyim Kasim, Sahyudin Saleh, Muhammad Ilyas, Arifin Seweng.

Abstract
Background: Acute kidney injury in malignant subjects can be caused by the process of the malignant itself or its therapy, in this case chemotherapy. Neutrophil Gelatinase Associated Lipocalin detects acute renal injury earlier than creatinine. This study measure the dynamics of Neutrophil Gelatinase Associated Lipocalin serum in malignant subjects treated with chemotherapy.
Method: Analytical research with cohort design. The research subjects were subjects aged > 18 years treated with chemotherapy at Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Serum level of Neutrophil Gelatinase Associated Lipocalin measured before and 24 hours after chemotherapy.
Results: Post-chemotherapy Neutrophil Gelatinase Associated Lipocalin serum level was significantly higher than pre-chemotherapy (280,330 ng / ml vs. 204,453 ng / ml, p 1.3 mg / dl compared to subjects with serum creatinine level < 1.3 mg / dl (185% vs 52%, p

Key words: Neutrophil Gelatinase Associated Lipocalin, acute kidney injury, malignancy, chemotherapy



Article Language: Turkish English


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