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Original Research

J Res Educ Indian Med . 2012; 18(3-4): 175-182


EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF COCCULUS HIRSUTUS LEAVES

S. SENGOTTUVELU, K. RAJESH, S. HAJA SHERIEF, R. DURAISAMI, M. VASUDEVAN, J. NANDHAKUMAR, D. KARTHIKEYAN, T. SIVAKUMAR.


Abstract

Inflammation and pain are the most common health problems treated with traditional
remedies which mainly comprise medicinal plants. A number of natural products are used in the
traditional medical systems in many countries. An alternative medicine for the treatment of various
diseases is getting more popular. Many medicinal plants provide relief of symptoms comparable to
that of obtained from allopathic medicines. Therefore agents of natural origin with very little side
effects are required as substitute chemicals therapeutics. The methanolic leaf extract of Cocculus
hirsutus (100 and 200 mg/kg) Linn (Menispermaceae) was investigated for its analgesic and antiinflammatory
effects in animals. The analgesic activity of the methanolic leaf extract of Cocculus
hirsutus was investigated by eddy’s hot plate model and acetic acid induced writhing in mice. Antiinflammatory
activity of Cocculus hirsutus was studied by both in vitro and in vivo models. Human
red blood cells membrane stabilization method was adopted for the in vitro anti-inflammatory activity
and for in vivo, carrageenan induced paw edema and cotton pellet induced granuloma in rats was
employed. In eddy’s hot plate analgesic study, both the doses of Cocculus hirsutus showed
significant (p

Key words: Cocculus hirsutus, Analgesic, Anti-inflammatory, HRBC.






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