An open randomized clinical trial was conducted to evaluate the efficacy of
Ayurvedic drug (Vacha Brahmi Ghan tablets) in clinically diagnosed and confirmed 110 patients
belonging to the age group of 20-60 yrs with the symptoms of Manodwega (Anxiety neurosis)
like fear (bhaya), excessive sweating (swedabahulayta), indecisive (asthairya), palpitation (hritkampa),
fatigue (anavasthitachittata), breathlessness (swaskrichchhata), trembling (vepathu), sleeplessness
(anidra), unexplained stomach aches (udarsula), frequent headaches (sirahsula), nausea (utklesha),
dryness in mouth (mukhasushkata), chest pain (urahsula) and giddiness (bhrama). The trial drug
was administered in the dose of 500 mg thrice times in a day with lukewarm water for six weeks.
Overall response at the end of the study was rated to be good in 9.18%, fair 70.40% and poor
16.32% of the patients. No adverse effects were reported. Statistically the result was determined
significant (p
Key words: Ayurveda, Traditional medicine, Acorus calamus, Bacopa monnieri, Anxiety neurosis,
Manodwega, Mental Health, Manas roga.
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