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Original Research

J Res Educ Indian Med . 2011; 17(3-4): 83-87


EFFECT OF URTICA DIOICA AND PICRORHIZA SCROPHULARIIFLORA EXTRACT ON STREPTOZOTOCIN INDUCED TYPE 1 DIABETIC MODEL RATS

M. DAS, R. PARIAL, B. P. SARMA, B. ROKEYA, L. ALI.




Abstract

This experiment evaluated the effect of the aqueous extract of Urtica dioica leaves
and the ethanolic extract of Picrorhiza scrophulariiflora rhizome on the glycemic and lipidemic
status in type 1 diabetic model rats. Adult Long Evans male rats, bred at BIRDEM animal house,
Dhaka, Bangladesh were used in this study. Type 1 diabetic model rats were produced with a single
intraperitoneal injection of Streptozotocin using standardized method used in BIRDEM. Serum
glucose was estimated by the glucose-oxidase (GOD-PAP) method, serum lipid profiles (cholesterol,
triglycerides, HDL) were measured by enzymatic colorimetric (cholesterol oxidase / peroxidase)
method. Significant blood glucose lowering effect of U. dioica (p

Key words: Type 1 diabetes, Streptozotocin, Urtica dioica, Picrorhiza scrophulariiflora, Animal model, Glycemic status, Lipidemic status.






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