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Original Research

J Res Educ Indian Med . 2011; 17(1-2): 53-56


AN OPEN LABEL EFFICACY AND SAFETY, PILOT TRIAL WITH POLYHERBAL ALL DAY MOISTURIZING CREAM IN PATIENTS WITH DRY AND SCALY SKIN

CHANDA KULKARNI, S. SUJATHA, PRAGYA S. KHARE, VINEETHA MATHEW, A.S. MOHAMMAD, ELIZABETH JAYASHEELAN.




Abstract

The aim of the study was to evaluate efficacy and safety of all day moisturizing, polyherbal
cream in the treatment of photosensitive, dry and scaly skin. Cream formulation containing heterogenous
herbal ingredients in various concentrations - Prunus amygdalus, Saccharum spontaneum, Hedychium
spicatum and Alpinia galanga, reported to have - emollient, anti-infective, anti-oxidant and anti-allergic
properties was tested for its skin moisturizing effects. Patients following assessment on clinical examination
by the dermatologist and baseline value for moisture content of 50 or less recorded using Moist Sense
instrument were considered for the study. The moisturizing efficacy was assessed during each visit on three
occasions - day zero, also on day fifteen and day thirty on completion of treatment. Patients were assessed
clinically by the dermatologist; subjectively using visual analogue scale (VAS) and objectively for the moisture
content by Moist Sense instrument. Among twenty four patients who completed the study, > 50%
improvement of skin hydration was seen on day 30 in 21/24 patients, following both subjective and objective
assessment. The values for moisture content assessed with the instrument, showed significant improvement
by Freedman’s test [P = 0.008]. The present study with all day moisturizing cream containing heterogenous
herbal ingredients for dry and scaly skin, in a limited number of patients showed beneficial effects. However,
study in larger number of patients is necessary to confirm the above results.

Key words: Photosensitive, Dry and scaly skin, Moisturizing cream, Polyherbal.






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