A number of popular preparations of Guggulu are being practiced for the treatment of many vatavyadhis and other related disorders. Aamvata (Rheumatoid arthritis), is a very common disease throughout the world. It is a chronic systemic inflammatory disorder, which affects the joints of the body causing painful swelling in them. It makes life miserable and crippling due to unknown causation, claiming the maximum loss of human working power. 109 cases along with involvement of joints having clinical features of Aamvata were selected and diagnosis was confirmed on the basis of proforma advocated by Central Rouncil for Research in Ayurveda and Siddha. The study indicates significant improvement in the clinical parameters, ESR, R.A. titre. Almost all cases whichever completed the treatment, improved from their signs and symptoms, therefore, the Ayurvedic compound drug Sunthi, Guggulu and Godanti (1:2:1) is found to be effective with no side effects and toxicity in the management of Aamvata.
Key words: Guggulu, Aamvata, Rheumatoid arthritis, Commiphora Wightii Bhan.