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Original Article

J App Pharm Sci. 2015; 5(9): 097-099


Perusal of Mbl2 Gene -Susceptibility to Tuberculosis in Different Indian Populations

C. V. Umesh, A. M. Jamsheer, Prasad M Alex, P K Krishnan Namboori.




Abstract

The tuberculosis (TB) is a major infectious disease in the world, which is still not made under control. Mannose binding lectin (MBL) or MBL2 is a human gene susceptible to Tuberculosis and is used as a tool to investigate the proneness of attack by mycobacterium tuberculosis. MBL2 gene has been found over fifty five different populations in India. Among the identified single-nucleotide polymorphism (SNP) investigated in this work by evaluating the SNPs through computational methods. All identified SNPs are reported as deleterious. The SNP, rs1800450 of MBL2 is commonly reported from all major genomic populations in India, and the individuals holding this SNP are prone to the attack of mycobacterium tuberculosis.

Key words: MBL2 Gene, Tuberculosis, SIFT, Damaging, SNP






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