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Original Article

BTDMJB. 2016; 12(1): 24-32


The predictive and prognostic value evaluation of serum extracellular matrix proteins levels in patients with pancreas adenocarcinoma

Senem Karabulut, Mehmet Karabulut, Halil Alış, Nergiz Dağoğlu, Makbule Tambaş, Selin Kapan, Ebru Oran, Hilal Oğuz, Faruk Taş.

Abstract
Objective: Fibronectin (FN),vitronectin (VTN), and tip IV kollagen (Kol IV) are the important components of the extracellular matrix (ECM) proteins. The objective of this study was to determine the clinical significance of serum levels of these molecules in pancreas adenocarcinoma (PA) patients.
Material and Methods: A total of 33 patients with a pathologically confirmed diagnosis of PA and age- and sex-matched 30 healthy controls were enrolled into this study. Serum FN, VTN, and Kol IV concentrations were determined by the enzyme-linked immuno-sorbent assay (ELISA) method.
Results: The median age at diagnosis was 59 years, range 32 to 84 years where 61% of the patients were male. Majority of the patients (70%) had good performance status (0-1). The most common tumor localization was head of pancreas (68%). Of the 9 patients who undergone surgical intervention, 5 patients (15%) had pancreaticoduodenectomy, while palliative surgery was performed in the remaining 4 (12%) patients. The baseline serum FN, VTN, and Kol IV levels were significantly higher in patients with PA than in the healthy control group (p=0.001, p=0.007 and p

Key words: Pancreas adenocarcinoma, fibronectin, vitronectin, Tip IV kollagen, diagnosis



Article Language: Turkish English



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