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Case Report

Düşünen Adam. 2016; 29(2): 167-172

Aripiprazole augmentation of clomipramine therapy in treatment-resistant obsessive-compulsive disorder: case series

Filiz Izci, Murat Yalcin, Sumeyye Yasemin Kurtulus Calli, Yagmur Sever, Rabia Bilici.

Obsessive-compulsive disorder (OCD) is a chronic disorder characterized by recurrent intrusive thoughts and repetitive rituals, causing significant distress and functional loss. Studies show evidence about serotonergic and dopaminergic mechanisms in neuropathogenesis of OCD. Selective serotonin re-uptake inhibitors (SSRI) are considered first line treatment in OCDs, but treatment resistance may occur in 40-60% of cases treated with SSRIs. Augmentation of antidepressants with atypical antipsychotics is an important treatment option in treatment-resistant patients with OCD. In this article, we aimed to present five OCD cases with treatment-resistance in which we obtained good outcomes, with addition of aripiprazole 10-30mg per day to clomipramine therapy.

Key words: Aripiprazole, clomipramine, obsessive-compulsive disorder, treatment resistance

Article Language: Turkish English

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