Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research

Egypt. J. Exp. Biol. (Zoo.). 2011; 7(2): 153-161


HISTOLOGICAL STUDY ON THE STOMACH OF IMMOBILIZED - STRESSED ALBINO RAT AND THE CURATIVE ROLE OF DIAZEPAM

Gabry M. Sayed, El–Desouki N. Ibrahim, El-Refaiy A. Ibrahim, Ibrahim M. Abd-Elrahman, Mohamed H. Nagy.

Abstract
The present work is planned to study the histopathological changes that may occur in the stomach of the immobilized-stressed rats and the possible curative role of diazepam injected intraperitoneally with therapeutic dose (0.1 mg / kg BW) daily for 30 days. Eighty adult male albino rats weighing 110 ± 5 g were used and divided equally into eight groups, group(Š†) served as control rats; group(Š†Š†) rats treated with diazepam; group (Š†Š†Š†) , (Š†V), and (V)served as stressed rats (10 animals each): in which the rats were immobilized individually for 2 hrs / day for different durations ( 5 , 15, and 30 days, respectively); groups (VI), (VII), and (VIII) served as immobilized- stressed rats (10 animals each) for 2 hrs / day for 5, 15 and 30 days and treated with diazepam for 30 days, respectively. The results recorded a significant increase in sera cortisol of the stressed - rats for 5, 15, and 30 days. Histological results of stomach demonstrated hypertrophy of parietal cells, detachment of gastric cells from the basement membrane, degeneration of the gastric glandular cells and irregular topography of the gastric gland. Appearance of karyolytic and pyknotic nuclei was also seen. Infiltration of inflammatory cells in lamina propria of mucosa was elucidated as well as congestion and dilatation of blood vessels. Moreover, the increment of collagen fibres in the lamina propria of mucosa and submucosa of the stressed rats was obviously demonstrated. These alterations were time-depended. Treatment with diazepam resulted in marked improvement and restoration of the histological changes. The results indicated that diazepam is recommended to be used as a curative drug to improve the disturbances in the stomach caused under the effect of stress.

Key words: Histology, Stomach, Rat, Stress, Benzodiazepines



Share this Article


Advertisement
Progress in Orthopedic Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.