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Egypt. J. Exp. Biol. (Zoo.). 2011; 7(1): 93-100


HISTOLOGICAL AND ULTRASTRUCTURAL STUDIES ON CHEMOPREVENTIVE EFFECT OF SPIRULINA PLATENSIS ON INDUCED MAMMARY CARCINOMA IN RATS

Amira O. Abd-El-Azim, Attalla F. El-Kott, Sherif H. Abdeen, Yahia A. Azab, Mohamed F. Ismail.

Abstract
Spirulina platensis is a filamentous cyanobacterium microalga with potent dietary phyto-antioxidant, anti-inflammatory and anti-cancerous properties. The present study aimed to investigate the curative effect of Spirulina platensis against mammary carcinoma in rats induced by 7, 12-Dimethylbenz[a]anthracene (DMBA). Investigation by light and electron microscopy showed that DMBA treatment induced breast carcinoma and histopathological abnormalities, which were ameliorated by Spirulina platensis supplementation. In the present investigation, histopathologiacal examination of the epithelium of the mammary gland of DMBA-treated rats showed that the developed cancer in treated groups could be classified into three types: 1) Lobular carcinoma in situ, 2) Comedo carcinoma, 3) Carcinoma simplex. Spirulina was found to be a successful anti-cancer therapy decrease uncontrolled cell growth against DMBA carcinogenicity. Moreover, unlike any other anti-cancer drugs or radiotherapy, Spirulina was found to be safe without any side effect or damage to the intact tissues.

Key words: Breast cancer, histology, ultrastructure, DMBA, Spirulina platensis.



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