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Egypt. J. Exp. Biol. (Zoo.). 2009; 5(0): 383-388


CHEMOPROTECTION OF ACUTE RENAL FAILURE IN RATS BY NARINGIN

Attalla F. El-kott, Abd El-karim M. Abd El-latif, Mohamed F. Ismail.

Abstract
To investigate the effect of naringin on acute renal failure, we used a rat model of acute tubular necrosis induced by glycerol. After deprivation of water for 24h, the rats received an injection with 10ml/kg body weight of 50% glycerol into the muscle of the rear limb. Naringin was then administered orally to the experimental rats (300mg/kg body weight/day). The rats with acute renal failure (ARF) showed arrested body weight gain and an increase in the kidney weight (P

Key words: Naringin, acute renal failure, nephrotoxic agents


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