Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research

Egypt. J. Exp. Biol. (Zoo.). 2008; 4(0): 237-242


EXPERIMENTAL STUDIES ON DICOFOL TOXICITY IN ADULT MALE ALBINO RATS

Mohamed FF. Bayomy, Hesham E. Abbas, Afaf A. EL-Kashoury, Safaa MS. Abou El-Soud.

Abstract
The present study was conducted to assess the adverse effects of exposure to dicofol pesticide on male albino rats. Two equal groups of rats were daily administered dicofol with high- and low-dose of dicofol (1/20 and 1/80 LD50, i.e. 32.5 and 8.13 mg/kg body weight, respectively.) for 3 months through drinking water. The third group received water only and was kept as control. At the end of three months dosing period, haemoglobin content, activities of certain serum enzymes, urea, and the levels of glucose, creatinine and some hormones were measured. The results were as follows: dicofol decreased red blood cells (RBCS), and white blood cells (WBCS) counts, packed cell volume (PCV) and haemoglobin (Hb) to reach the lowest level in high dose group compared with the low and control groups. However, the pesticide administration increased glucose level and the activity of serum aminotransferases (AST & ALT) activities at high dose group when compared with the low dose and control groups. Dicofol increased also, urea and creatinine levels. The group of rats which was exposed to high dose of dicofol had the lowest levels of testosterone and leutinizing hormone (LH) (p

Key words: Dicofol, organochlorine acaricide, toxicity testing, testosterone, female sex hormones


Full-text options

Full-text Article


Share this Article


Readers of this article also read the following articles
»Screening Of Antýbodies Against Cytomegalovirus and Rubella Virus In Childbearing Age?s Women
»Microsurgical reimplantantion of a self-amputated penis with anastomosis of a single deep dorsal penile artery: Case report
»Evaluation of antioxidant vitamins among roadside gasoline dispensers in Gombe, Nigeria
» Ecstasy use complicating with ICA dissection; A case report
»The effects of short-interval postconditioning in preventing muscle ischemia-reperfusion injury in rats
»The Relationship Between Ýmpact Of Pregnancy Complaints On The Life Quality Of The Pregnant Women And Their Psychosocial Health Level
»Sociodemographic Characteristics of Spinal Tuberculosis Patients
»The Use of Patient-Specific Intra-Operative Guides for Total Knee Arthroplasty (TKA)
»Prevalence, Gender Distribution and Presence of Attention Deficit Hyperactivity Disorder by Certain Sociodemographic Characteristics Among University Students
»Some Studies on The Health Status and Productivity of Rice - Cultured Tilapia
»AcutAcute dystonic reaction due to metoclopramide use in a 9-year-old patient



Advertisement
Oxidants and Antioxidants in Medical Science

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.