The present study aimed to evaluate the potential protective effect of honey or the ethanolic extract of Zizyphus spina christi leaves against kava Piper methysticum extract toxicity. Oral administration of kava at a dose of 1 g/kg BW to male albino rats did not cause any significant changes in the RBCs count and PCV value, whereas, it increased WBCs count and Hb content. Toxicity of kava was observed by increased activities of serum ASAT, ALAT, ALP and LDH enzymes. No significant changes were recorded in the serum glucose, triglycerides, total cholesterol, total protein and albumin levels after administration of kava for 14 days, while serum urea and creatinine levels were elevated significantly as compared to the control values. Concomitant administration of honey or the ethanolic extract of Z. spina leaves with kava ameliorated the toxic changes caused by kava in the Hb content, WBCs count, activities of serum enzymes (ASAT, ALAT, ALP, LDH), albumin, urea and creatinine levels.
Key words: Kava-Piper methysticum Honey Zizyphus spina christi hepatoprotection blood metabolites serum.
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